Abstract: Delafloxacin (DLX) is a recently-approved fluoroquinolone antibiotic, which is recommended\nfor the treatment of â??acute bacterial skin and skin structure infectionsâ?. A thorough literature survey\nrevealed only a single published method for the estimation of DLX using UPLC-MS/MS technique in\nbiological samples. There is no high-performance thin-layer chromatography (HPTLC) method has been\nreported for the estimation of DLX in dosage forms and/or biological samples. Therefore, a selective,\nsensitive, rapid and validated HPTLC-densitometry technique has been used for the estimation of DLX in\nhuman plasma for the first time. HPTLC quantification of DLX and internal standard (IS; gatifloxacin)\nwas carried out on glass coated silica gel 60 F254 HPTLC plates using the ternary mixture of ethyl\nacetate:methanol:ammonia solution 5:4:2..............
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